臍帶間質幹細胞的外泌體,透過自噬作用,修復巴金森氏症模型
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臍帶間質幹細胞外泌體的驚人潛力!透過SH-SY5Y細胞模擬多巴胺神經細胞的實驗,結果顯示外泌體不僅能顯著增強自噬作用,促進資源回收與細胞修復,甚至在抑制自噬的藥物影響下,仍展現強大的修復效果。與幹細胞相比,外泌體更穩定、保存成本低、易穿過血腦屏障,且無繁殖或成流性風險。這項突破性發現證實了外泌體在減少細胞凋亡、增強活力及提升多巴胺濃度上的效果,開啟了治療多巴胺相關疾病的新希望!
The remarkable potential of umbilical mesenchymal stem cell exosomes! Through experiments using SH-SY5Y cells to model dopamine neurons, the results show that exosomes not only significantly enhance autophagy, promoting resource recycling and cell repair, but also demonstrate powerful repair effects even in the presence of autophagy inhibitors. Compared to stem cells, exosomes are more stable, have lower storage costs, are easily able to cross the blood-brain barrier, and pose no risk of reproduction or tumor formation. This groundbreaking discovery confirms the exosomes' effectiveness in reducing cell apoptosis, boosting vitality, and increasing dopamine levels, opening up new possibilities for the treatment of dopamine-related diseases.